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Blog posts : "Publications"

High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs (2021) PLoS Genetics

Akhtari FS, Green AJ, Small GW, Havener TM, House JS, Roell KR, Reif DM, McLeod HL, Wiltshire T, Motsinger-Reif AA. High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticance…

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Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology (2021) PLoS Comput Biol

Green AJ, Mohlenkamp MJ, Das J, Chaudhari M, Truong L, Tanguay RL, et al. (2021) Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology. PLoS Comput Biol 17(7): e1009135. https://doi.org/10.1371/journal.pcbi.1…

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Concurrent evaluation of mortality and behavioral responses: A fast and efficient testing approach for high-throughput chemical hazard identification (2021) Frontiers in Toxicology

 
10.3389/ftox.2021.670496

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Extending the lymphoblastoid cell line model for drug combination pharmacogenomics (2021) Pharmacogenomics

Green AJ, Anchang B, Akhtari FS, Reif DM, Motsinger-Reif A. Extending the lymphoblastoid cell line model for drug combination pharmacogenomics. Pharmacogenomics. 2021 May 28. doi: 10.2217/pgs-2020-0160. Epub ahead of print. PMID: 34044623.

https://pubmed.ncbi.nlm.nih.gov/34044623/

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Multiomic Big Data Analysis Challenges: Increasing Confidence in the Interpretation of Artificial Intelligence Assessments (2021) Analytical Chemistry

Odenkirk MT, Reif DM, Baker ES. Multiomic Big Data Analysis Challenges: Increasing Confidence in the Interpretation of Artificial Intelligence Assessments. Anal Chem. 2021 May 24. doi: 10.1021/acs.analchem.0c04850. Epub ahead of print. PMID: 34029068.

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Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions (2021) Toxics

Wallis DJ, Truong L, La Du J, Tanguay RL, Reif DM. Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions. Toxics. 2021; 9(4):77. https://doi.org/10.3390/toxics9040077

Abstract

Exposure to endocrine-disrupting che…

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Development of a Pandemic Awareness STEM Outreach Curriculum: Utilizing a Computational Thinking Taxonomy Framework (2021) Education Sciences

Gilchrist PO, Alexander AB, Green AJ, Sanders FE, Hooker AQ, Reif DM. Development of a Pandemic Awareness STEM Outreach Curriculum: Utilizing a Computational Thinking Taxonomy Framework. Education Sciences. 2021; 11(3):109. https://doi.org/10.3390/educsci11030109

Abstract

Computational thin…

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Children's Environmental Health: A Systems Approach for Anticipating Impacts from Chemicals (2020) Int J Environ Res Public Health

DOI: 10.3390/ijerph17228337

Cohen Hubal EA, Reif DM, Slover R, Mullikin A, Little JC. Children's Environmental Health: A Systems Approach for Anticipating Impacts from Chemicals. Int J Environ Res Public Health. 2020 Nov 11;17(22):8337. doi: 10.3390/ijerph172…

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Graphic by Melanie Odenkirk makes the cover of the journal Analyst

https://pubs.rsc.org/en/content/articlelanding/2020/an/d0an90119a#!divAbstract

 

From the article: 

Structural-based connectivity and omic phenotype evaluations (SCOPE): a cheminformatics toolbox for investigating lipidomic changes in complex systems.

Odenkirk MT , Zin PPK , Ash JR , R…

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[COVER ARTICLE] Structural-based connectivity and omic phenotype evaluations (SCOPE): a cheminformatics toolbox for investigating lipidomic changes in complex systems (2020) Analyst

2020 Nov 9;145(22):7197-7209.
 doi: 10.1039/d0an01638a.

Structural-based connectivity and omic phenotype evaluations (SCOPE): a cheminformatics toolbox for investigating lipidomic changes in complex systems

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The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity (2020) Reproductive Toxicology

The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity. Truong L, Marvel S, Reif DM, Thomas D, Pande P, Dasgupta S, Simonich MT, Waters KM, Tanguay RL.Reprod Toxicol. 2020 Aug 19:S0890-6238(20)30196-9. doi: 10.1016/j.reprotox.2020.08.007. Online ahead of print.PMID:…

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The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning (2021) Environmental Health Perspectives

Marvel SW, House JS, Wheeler M, Song K, Zhou YH, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning. Environ Health Perspect. 2021 Jan…

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In vivo assessment of respiratory burst inhibition by xenobiotic exposure using larval zebrafish (2020) Immunotoxicology

Drake W. Phelps, Ashley A. Fletcher, Ivan Rodriguez-Nunez, Michele R. Balik-Meisner, Debra A. Tokarz, David M. Reif, Dori R. Germolec & Jeffrey A. Yoder (2020) In vivo assessment of respiratory burst inhibition by xenobiotic exposure using larval zebrafish, Journal of Immunotoxicology, 17:1, 94-104,…

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Adrian Green presents at Statistical and Applied Mathematical Sciences Institute

Adrian will present his work on Deep Learning Neural Networks for Toxicology with Martin Mohlenkamp and the Novel Applications team.

https://www.samsi.info/programs-and-activities/semester-long-programs/past/2019-fall-semester-program-on-deep-learning/

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Paper on social behavior effects of flame retardants (Gillera et al.) recognized as NIEHS Extramural Paper of the Month

https://factor.niehs.nih.gov/2020/1/papers/dert/index.htm

 

Gillera SEA, Marinello WP, Horman BM, Phillips AL, Ruis MT, Stapleton HM, Reif DM, Patisaul HB. 2019. Sex-specific effects of perinatal FireMaster 550 (FM 550) exposure on socioemotional behavior in prairie voles. Neurotoxicol Tera…

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HGBEnviroScreen: Enabling Community Action through Data Integration in the Houston–Galveston– Brazoria Region (2020) International Journal of Environmental Research and Public Health

Sharmila Bhandari, P. Grace Tee Lewis, Elena Craft, Skylar W. Marvel, David M. Reif, and Weihsueh A. Chiu. HGBEnviroScreen: Enabling Community Action through Data Integration in the Houston–Galveston–Brazoria Region. Int. J. …

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Concentration-response evaluation of ToxCast compounds for multivariate activity patterns of neural network function (2019) Arch Toxicol

Kosnik MB, Strickland JD, Marvel SW, Wallis DJ, Wallace K, Richard AM, Reif
DM, Shafer TJ. Concentration-response evaluation of ToxCast compounds for
multivariate activity patterns of neural network function. Arch Toxicol. 2019 Dec
10. doi: 10.1007/s00204-019-02636-x. [Epub ahead of print] PubM…

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Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles (2019) Neurotoxicology and Teratology

Gillera SEA, Marinello WP, Horman BM, Phillips AL, Ruis MT, Stapleton HM, Reif
DM, Patisaul HB. Sex-specific effects of perinatal FireMaster® 550 (FM 550)
exposure on socioemotional behavior in prairie voles. Neurotoxicol Teratol. 2019 
Nov 12:106840. doi: 10.1016/j.ntt.2019.106840. [Epub ahead…

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Multivariate modeling of engineered nanomaterial features associated with developmental toxicity (2019) NanoImpact

 

KT To, L Truong, S Edwards, RL Tanguay, DM Reif (2019) Multivariate modeling of engineered nanomaterial features associated with developmental toxicity, NanoImpact.

 

 

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Synergistic chemotherapy drug response is a genetic trait in lymphoblastoid cell lines (2019) Frontiers in Genetics

Kyle Roell, Tammy Havener, David Reif*, John Jack, Howard McLeod, Tim Wiltshire, Alison Motsinger-Reif*

Front. Genet. | doi: 10.3389/fgene.2019.00829

Synergistic chemotherapy drug response is a genetic trait in lymphoblastoid cell lines

Lymphoblastoid cell lines (LCL) are a high…

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20 blog posts