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Blog posts : "Publications"

Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke (2022) Environ Int.

Carberry CK, Koval LE, Payton A, Hartwell H, Ho Kim Y, Smith GJ, Reif DM, Jaspers I, Ian Gilmour M, Rager JE. Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke. Environ Int. 2022 Jul 16;167:107419. doi: 10.1016/j.envint.2…

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Development of the InTelligence And Machine LEarning (TAME) Toolkit for Introductory Data Science, Chemical-Biological Analyses, Predictive Modeling, and Database Mining for Environmental Health Research (2022) Front. Tox

Kyle Roell, Lauren E. Koval, Rebecca Boyles, Grace Patlewicz, Caroline Ring, Cynthia V. Rider, Cavin Ward-Caviness, David M. Reif, Ilona Jaspers, Rebecca C. Fry and Julia E. Rager. Development of the InTelligence And Machine LEarning (TAME) Toolkit for Introductory Data Science, Chemical-Biological …

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Comparison of National Vulnerability Indices Used by the Centers for Disease Control and Prevention for the COVID-19 Response (2022) Public Health Reports

Wolkin A, Collier S, House J, Reif D, Motsinger-Reif A, Duca L, Sharpe D. Comparison of National Vulnerability Indices Used by the Centers for Disease Control and Prevention for the COVID-19 Response. Public Health Rep. 2022 May 5:333549221090262. doi: 10.1177/00333549221090262. Epub ahead of print.…

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Principles of Toxicology: Environmental and Industrial Applications, 4th Edition

Principles of Toxicology: Environmental and Industrial Applications, 4th Edition. Stephen M. Roberts (Editor), Robert C. James (Editor), Phillip L. Williams (Editor). ISBN: 978-1-119-63516-1.

David Reif co-authored Chapter 6 "Computational Toxicology", with Richard S. Judson, David M. Reif, Keit…

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Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility Differences in a Genetically Diverse Zebrafish Model (2022) Frontiers in Toxicology

Dylan James Wallis, Jane La Du, Preethi Thunga, Daniel Elson, Lisa Truong, Siva Kumar Kolluri, Robyn Leigh Tanguay, David M Reif. Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility Differences in a Genetically Diverse Zebrafish Model. 29 April 2022. Fro…

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ToxPi*GIS Toolkit: creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS (2022) J Expo Sci Environ Epidemiol.

Fleming J, Marvel SW, Supak S, Motsinger-Reif AA, Reif DM. ToxPi*GIS Toolkit: creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS. J Expo Sci Environ Epidemiol. 2022 Apr 26. doi: 10.1038/s41370-022-00433-w. Epub ahead of print. PMID: 35474345.

doi: 10.1038/s…

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Convergent evolution of polyploid genomes from across the eukaryotic tree of life (2022) G3

Hao Y, Fleming J, Petterson J, Lyons E, Edger PP, Pires JC, Thorne JL, Conant GC. Convergent evolution of polyploid genomes from across the eukaryotic tree of life. G3 (Bethesda). 2022 Apr 22:jkac094. doi: 10.1093/g3journal/jkac094. Epub ahead of print. PMID: 35451464.

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The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior (2022) Toxicological Sciences

Shankar P, Garcia GR, LaDu JK, Sullivan CM, Dunham CL, Goodale BC, Waters KM, Stanisheuski S, Maier CS, Thunga P, Reif DM, Tanguay RL. The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Toxicol Sci. 2022 Apr 4:kfac037. doi: 10.1093/toxsci/kfac037. Epub ahead …

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Kirkwood et al. pub recognized as "NIEHS Paper of the Month"

https://factor.niehs.nih.gov/2022/4/papers/dert/index.htm

Pine needles work as passive samplers for PFAS

NIEHS-funded researchers showed that pine needles can be used as a tool to monitor the presence and distribution of per- and polyfluoroalkyl substances (PFAS) over time. The pine needle’s w…

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Implementation of Zebrafish Ontologies for Toxicology Screening (2022) Frontiers in Toxicology

Anne E Thessen, Skylar Marvel, J. C. Achenbach, Stephan Fischer, Melissa Anne Haendel, Kimberly Hayward, Nils Klüver, Sarah Könemann, Jessica Legradi, Pamela J Lein, Connor Leong, Arantza Muriana, J. Erik Mylroie, Stephanie Padilla, Dante Perone, Antonio Planchart, Rafael Miñana Prieto, Celia Queved…

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Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish (2022) J Hazard Mater

Truong L, Rericha Y, Thunga P, Marvel S, Wallis D, Simonich MT, Field JA, Cao D, Reif DM, Tanguay RL. Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish. J Hazard Mater. 2022 Mar 2;431:128615. doi: 10.1016/j.jhazmat.2022.128615. Epub ahead of print. P…

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Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances (2022) Environ Sci Technol.

Kirkwood KI, Fleming J, Nguyen H, Reif DM, Baker ES, Belcher SM. Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances (PFAS). Environ Sci Technol. 2022 Feb 17. doi: 10.1021/acs.est.1c06483. Epub ahead of print. PMID: 35175744.

https://pubmed.ncbi.nlm.nih.…

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Collaborative paper featuring Jonathon's work highlighted in the news

https://news.ncsu.edu/2022/02/pine-needles-story-of-nc-pfas/

Pine Needles Tell the Story of PFAS in North Carolina

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Demonstrating a systems approach for integrating disparate data streams to inform decisions on children's environmental health (2022) BMC Public Health

Hubal EAC, DeLuca NM, Mullikin A, Slover R, Little JC, Reif DM. Demonstrating a systems approach for integrating disparate data streams to inform decisions on children's environmental health. BMC Public Health. 2022 Feb 15;22(1):313. doi: 10.1186/s12889-022-12682-3. PMID: 35168583; PMCID: PMC8845296…

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High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs (2021) PLoS Genetics

Akhtari FS, Green AJ, Small GW, Havener TM, House JS, Roell KR, Reif DM, McLeod HL, Wiltshire T, Motsinger-Reif AA. High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticance…

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Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology (2021) PLoS Comput Biol

Green AJ, Mohlenkamp MJ, Das J, Chaudhari M, Truong L, Tanguay RL, et al. (2021) Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology. PLoS Comput Biol 17(7): e1009135. https://doi.org/10.1371/journal.pcbi.1…

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Concurrent evaluation of mortality and behavioral responses: A fast and efficient testing approach for high-throughput chemical hazard identification (2021) Frontiers in Toxicology

 
10.3389/ftox.2021.670496

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Extending the lymphoblastoid cell line model for drug combination pharmacogenomics (2021) Pharmacogenomics

Green AJ, Anchang B, Akhtari FS, Reif DM, Motsinger-Reif A. Extending the lymphoblastoid cell line model for drug combination pharmacogenomics. Pharmacogenomics. 2021 May 28. doi: 10.2217/pgs-2020-0160. Epub ahead of print. PMID: 34044623.

https://pubmed.ncbi.nlm.nih.gov/34044623/

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Multiomic Big Data Analysis Challenges: Increasing Confidence in the Interpretation of Artificial Intelligence Assessments (2021) Analytical Chemistry

Odenkirk MT, Reif DM, Baker ES. Multiomic Big Data Analysis Challenges: Increasing Confidence in the Interpretation of Artificial Intelligence Assessments. Anal Chem. 2021 May 24. doi: 10.1021/acs.analchem.0c04850. Epub ahead of print. PMID: 34029068.

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Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions (2021) Toxics

Wallis DJ, Truong L, La Du J, Tanguay RL, Reif DM. Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions. Toxics. 2021; 9(4):77. https://doi.org/10.3390/toxics9040077

Abstract

Exposure to endocrine-disrupting che…

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20 blog posts