Reif Lab

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Reif serves as Working Group member for the World Health Organization's (WHO) International Agency for Research on Cancer (IARC) monograph on Benzene

October 27, 2017

David Reif was a member of the Working Group that drew experts from around the world to a meeting in Lyon, France in order to evaluate the carcinogenicity of Benzene. 

Summaries of the final evaluations are available in the Lancet Oncology article. The detailed assessments will be published as …

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Reif presents at Environmental Mutagenesis & Genomics Society

September 24, 2017

David presented a seminar at the annual meeting of the Environmental Mutagenesis & Genomics Society (EMGS), entitled: "Gene-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure".

Michele Balik-Meisner successfully defends her PhD!

August 23, 2017

Michele Balik-Meisner successfully defended her doctoral dissertation, entitled "Gene-by-Environment Interactions Associated with Inter-Individual Variation in Response to Chemical Exposure".  

Michele will continue her research as a Bioinformaticist at Sciome

Congratulations!!!

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Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups (2017) ALTEX

August 22, 2017

Reif presents at OpenTox conference

July 12, 2017

David Reif presented at the 2017 OpenTox USA meeting. Thanks to Barry Hardy and Noffisat Oki for the invitation to speak! 

His seminar was entitled "Implications of Population Genetic Diversity for Safety Assessment."  

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Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo [a] pyrene in zebrafish (2017) Toxicology and Applied Pharmacology

June 3, 2017
Knecht AL, Truong L, Marvel SW, Reif DM, Garcia A, Lu C, Simonich MT,
Teeguarden JG, Tanguay RL. Transgenerational inheritance of neurobehavioral and
physiological deficits from developmental exposure to benzo[a]pyrene in
zebrafish. Toxicol Appl Pharmacol. 2017 Jun 3;329:148-157. doi:
10.1016/…

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Reif presents at International Neurotoxicology Association meeting in Brazil

May 22, 2017

David Reif presented at the joint meeting of the International Neurotoxicology Association & Neurotoxicity Society in Florianopolis, Brazil. 

The seminar was entitled "Developing an Integrated Testing Strategy: Analytical methods to distill useful information from high-throughput screening of ch…

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Reif, Kosnik, and Hoppin present at the University of Wollongong, Australia

May 3, 2017

David Reif, Marissa Kosnik, and Jane Hoppin traveled to Australia to present and collaborate with researchers at the University of Wollongong. The trip was sponsored by a grant from the University Global Partnership Network (UGPN). Our hosts were Thomas Astell-Burt and Xiaoqi Feng, who direct the Po…

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An introduction to terminology and methodology of chemical synergy -perspectives from across disciplines (2017) Frontiers in Pharmacology

April 3, 2017

Reif presents at ToxForum annual meeting

February 15, 2017

David Reif presented an invited talk at the 41st Annual ToxForum Winter Meeting in Washington, DC.

The talk, "Integrating Multiple Sources of High-Dimensional Data to Quantify Effects of Genetic Variability in Chemical Risk Assessment", was part of a session moderated by Julia Rager & Reza Rasoulpo…

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Incorporating ToxCast and Tox21 datasets to rank biological activity of chemicals at Superfund sites in North Carolina (2017) Environment International

February 1, 2017

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Reif presents in Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) series

February 1, 2017

David Reif presented as part of the ongoing Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) webinar series. 

The Proximity Principle

February 1, 2017

Christy Sadler and colleagues have written a new multimedia article about the Bioinformatics "cluster" at NC State University.

https://sciences.ncsu.edu/news/the-proximity-principle

The term "cluster" is shorthand for the cluster hiring program known as the Chancellor's Faculty Excellence Prog…

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A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish (2017) PLoS One

January 18, 2017

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Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership (2016) PLoS One

December 12, 2016

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A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades (2016) TAAP

November 21, 2016
Zhang G, Roell KR, Truong L, Tanguay RL, Reif DM. A data-driven weighting
scheme for multivariate phenotypic endpoints recapitulates zebrafish
developmental cascades. Toxicol Appl Pharmacol. 2016 Nov 21. pii:
S0041-008X(16)30365-9. doi: 10.1016/j.taap.2016.11.010. [Epub ahead of print]
PubMed …

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Embryonic exposure to TCDD impacts osteogenesis of the axial skeleton in Japanese medaka, Oryzias latipes (2016) Toxicological Sciences

November 15, 2016

Embryonic exposure to TCDD impacts osteogenesis of the axial skeleton in Japanese medaka, Oryzias latipes. ALTD Watson, A Planchart, CJ Mattingly, C Winkler, DM Reif, SW Kullman. Toxicological Sciences, kfw229

http://toxsci.oxfordjournals.org/content/early/2016/11/14/toxsci.kfw229.full.pdf+html

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Eigenvector metabolite analysis reveals dietary effects on the association among metabolite correlation patterns, gene expression, and phenotypes (2016) Metabolomics

November 1, 2016

Eigenvector metabolite analysis reveals dietary effects on the association among metabolite correlation patterns, gene expression, and phenotypes. CHS Chialvo, R Che, D Reif, A Motsinger-Reif, LK Reed. Metabolomics 12 (11), 167.

http://link.springer.com/article/10.1007/s11306-016-1117-3

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Reif presents at Triangle Statistical Genetics Meeting

October 31, 2016

David Reif presented an invited talk at the 2016 Triangle Statistical Genetics Meeting. The event was hosted at SAS, Inc. by the Triangle StatGen Organizing Committee.

 

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Article featured as Editor's Highlight in Toxicological Sciences

August 1, 2016
Judson R, Houck K, Martin M, Richard AM, Knudsen TB, Shah I, Little S,
Wambaugh J, Woodrow Setzer R, Kothya P, Phuong J, Filer D, Smith D, Reif D,
Rotroff D, Kleinstreuer N, Sipes N, Xia M, Huang R, Crofton K, Thomas RS.
Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicit…

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20 blog posts